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At 68 weeks, treatment was stopped but a small group continued taking semaglutide for a year as part of an extension trial

Cagrilintide is a long-acting amylin analog that suppresses appetite through a pathway completely independent of GLP-1, while semaglutide provides the familiar GLP-1 receptor activation

However, these two natural GLP-1R agonists are rapidly digested by the enzyme DPP-4 and cleared by the kidneys within 1-2 minutes, making them unsuitable for direct therapeutic use

Back Laughton, NB, Macallum, AB (1 June 1932) 'The Relation of duodenal mucosa to internal secretion of the pancreas', Proceedings of the Royal Society of London

"We think of these medications like any other chronic medication, like a blood pressure pill or cholesterol pill," says Jay

Among them, GLP-1 and GIP (gastric inhibitory polypeptide) are known as incretins, gut-derived hormones that enhance glucose-dependent insulin secretion, playing a pivotal role in maintaining glucose homeostasis and serve as important therapeutic targets for type 2 diabetes and obesity