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Mic JA, Rojas-Corrales MO, Gibert-Rahola J, Parellada M, Moreno D, et al
Inflammation and oxidative stress are closely interconnected, as the cellular damage imposed by increases in oxidative stress prompts immune inflammatory responses which contribute to the development and severity of neurodegeneration (Heneka et al., 2015)
Glutathione is the end productthe actual antioxidant molecule that neutralizes free radicals
Moreover, exposure to IGF binding protein 5 (IGFBP5), the transport protein of IGF-1, provoked cellular senescence in human umbilical vein endothelial cells (HUVEC) [148] although the signaling pathway remained unknown
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