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Baseline demographic and clinical characteristics were generally descriptively similar for patients who initiated semaglutide and tirzepatide, suggesting that these treatments are used in similar patient populations in clinical practice

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The most common gene variant observed was Apo5 variants (10 patients), heterozygosity for LPL deficiency in 5 patients and one patient with the LMF-1 variant

Avoid taking calcium, iron, or mineral-heavy supplements within 2 hours of tirzepatide injection or oral dosing, as they can bind to the medication and reduce its effectiveness

The research picture is more nuanced than any single headline: some GLP-1 agents, at some doses, in some populations, may have bone-protective signaling effects