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They also confirmed that concurrent treatment with JHU083 and anti-PD-1 checkpoint inhibitor improved the antitumor effects compared with anti-PD-1 treatment alone, suggesting the presence of metabolic plasticity between cancer cells and effector T cells, which could be exploited as a metabolic checkpoint for cancer immunotherapy 200

It is believed to have antimicrobial and anti-inflammatory properties [232,233], mostly by downregulation of expression of pro-inflammatory cytokines and upregulation of the anti-inflammatory ones both in vitro and in vivo [232,234,235,236]

Particularly, we found the repression of lipogenic genes required a strong induction of NRF2 activity, as mild induction of NRF2 activity (0.510 11 pfu) was not sufficient to repress lipogenic gene expression

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