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Immunoreactivity of tyrosine hydroxylase (TH) in the substantia nigra and caudoputamen suggested its neuroprotective role against the degeneration of dopaminergic neurons

O., Jr, Farese, J

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One of the main molecular pathologic mechanisms in this setting is represented by -synuclein aggregation in mitochondria, which leads to the production of reactive oxygen species (ROS) and induces activation of p38 MAPK, a MAP-kinase that triggers the phosphorylation of Drp1 (dynamin-related protein-1), which eventually leads to mitochondrial fission (Lev et al., 2006)

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NAD powers your cells and supports energy and repair, while Glutathione protects your cells from damage and oxidative stress