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A meta-analysis in 2016 including 34 papers that measured changes in HDL-C levels before and after treatment with a GLP-1 RA found five studies showing a significant increase in HDL-C levels and 29 studies showing no significant change in HDL-C levels [69]

The authors reported that the combination was generally tolerated across the tested levels, with adverse events predominantly gastrointestinal and graded mild to moderate, and that the pharmacokinetic profile was consistent with once-weekly administration in the trial design

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