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The SHAP plots for both the RF and ET models highlighted several key factors contributing to the prediction of liver injury in COVID-19 patients

Specifically, in the morphine-induced constipation model mice, we demonstrate that morphine inhibits PVN Glu neuronal activity through MOR, thereby reducing DMV Ach neuronal activity, which leads to decreased small intestinal motility and a reduced transit rate, ultimately manifesting in constipation

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Metformin, on the other hand, has a much smaller effect on weight