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Factors affecting treatment outcomes Despite the existing, wide inter-individual variability in the concentrations of tamoxifen and its metabolites, there was no evidence linking variability in tamoxifen or its metabolite concentrations with patient response or side effects

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This delayed and inadequate labeling forms the basis for failure-to-warn claims, which argue that had patients and doctors received proper warnings about gastroparesis and vision loss risks, many would have chosen alternative diabetes medications or weight loss treatments