Closely following our GLP-1 program is our apelin/GLP-1 combination patch, which is designed to counter the lean-mass loss that accompanies GLP-1driven weight loss, a major challenge in the treatment of obesity.
Wong M et al
Lassailly G, Caiazzo R, Buob D, et al
ANALYSIS OF THE PATENT LANDSCAPE FOR SEMAGLUTIDE AND TIRZEPATIDE This section examines the patent thicket that Novo Nordisk and Eli Lilly have built around the drugs Ozempic, Rybelsus and Wegovy (semaglutide) and Mounjaro and Zepbound (tirzepatide)
Unlike other peptide medications that only target one specific area (GLP-1), tirzepatide has the ability to target two areas at once (GLP-1 & GIP)
Semaglutide can attenuate inflammation in MASLD by downregulating the IRE1-XBP1-C/EBP (inositol-requiring transmembrane kinase/endonuclease-1-X-box binding protein 1-CCAAT/enhancer binding protein ) pathway in macrophages ( 2 ( 4.1.2 GLP-1RAs regulate the immune cells to protect the liver against fibrosis and neoplasia Exenatide and liraglutide can elevate cAMP levels and reduce the M1/M2 ratio through the cAMP-PKA-STAT3 pathway, resulting in amelioration of injured liver function and liver inflammation (Li et al., 2022
