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Taking 300 mg of alpha-lipoic acid by mouth daily for 12 weeks does not seem to affect pain or inflammation in people with rheumatoid arthritis
The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12
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