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This improves energy expenditure, insulin sensitivity, and fat oxidation

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This is why researchers who buy retatrutide observe metabolic effects that cannot be replicated by combining semaglutide or tirzepatide alone

Lancet 396 (10248), 413446 (2020)

Instead, they are made in pharmacies when there is a medical reason, sometimes to help with possible B12 deficiencies that might happen during use