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The exact timeline varies by individual, making regular glucose monitoring essential during this transition period

Clinical trials show that weight loss plateaus around 1.0 to 2.0 mg for many patients, meaning higher doses may not produce additional significant weight loss

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While many hydrogel-based depot technologies have been reported in the literature to show attractive local tolerance ( 31 ), they typically exhibit several critical shortcomings, including: (i) complicated manufacturing and poor formulation stability, (ii) challenging administration, (iii) burst release that can contribute to poor tolerability of the therapy, and (iv) insufficiently slow release to enable appropriately long-acting therapies