These in vitro results demonstrated that H2O2 induces Leydig cell senescence, accompanied by FOXO4 nuclear translocation and activation of senescence pathways
S-ACETYL GLUTATHIONE AND DETOXIFICATION
Specifically, 2 mM FeSO 4 solution, 360 mg mL 1 safranine solution, 3% (wt%) H 2 O 2 solution, 0.1 M HCl (aq) and G/D-CuP were added to each well in a 96-well plate (n = 3)
Considering a three-dimensional structural model for a complex of the human HGF-NK2 segment sandwiched by c-met receptor molecules (see supplementary Figure 3, re-produced from PDB ID 7MO7 67 , it is hypothesized that the disulfide bonds, notably Cys149-Cys189 and Cys177-Cys201 localized internally just behind Y198, are the targets of LASSS
Alwahsh: Data curation, formal analysis, supervision, funding acquisition, investigation, methodology, writing-original draft, project administration, writing-review and editing
Research domains include cellular senescence, tissue aging, and experimental longevity models
