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But compelling preclinical data does not translate reliably to human outcomes

Chronic stress, maternal deprivation, and olfactory bulbectomy are among the models that present higher degrees of face validity (i.e., animal behavior correlates with MDD symptomatology), predictive validity (i.e., good chances of replicating the positive or negative results in human patients), and construct validity (i.e., consistent underlying pathology biomarkers, triggering factors, time course, and response to antidepressants)

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