The Orphan Drug designation indicates FDA recognition of its potential for conditions lacking adequate treatments
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It is not clear whether sulfite is responsible for the accumulation of -AASA and the deficiency in PLP in ISOD and MocoD patients
Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, et al
10.3389/fendo.2025.1596000 Summary Keywords artificial intelligence, diabetic kidney disease, metabolomics, precision medicine, single-cell RNA sequencing Citation Li T, Chen K, Sun Y and Zhang L (2026) Diabetic kidney disease: integrating multi-omics insights, artificial intelligence, and novel therapeutics for precision medicine