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A Mayo Clinic study found postmenopausal women using hormone therapy alongside tirzepatide (a GLP-1/GIP dual agonist) experienced notably greater weight loss compared with those using tirzepatide without HRT

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GLP-1 medications commonly cause nausea and GI distress

Despite the FDAs warning that unapproved incretin drugs such as compounded semaglutide and tirzepatide can be risky, their popularity too was reflected in the study

n = 6 / 7 biologically independent samples), unpaired 2-tailed t-test: t(11)=0.214, p = 0.834

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