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Retatrutide (12 mg weekly), TRIUMPH-4, 68 weeks: mean weight loss 28.7%
The incretin effect is reduced in people with T2DM, mainly because GIP has less of an impact [85]
Some patients notice initial improvements within one week, with optimal results developing around three months as collagen production increases
A liver substudy, an earlier Phase 2 secondary finding, showed the drug cleared fatty liver in most people on the higher doses, and there are programs running in sleep apnea, chronic kidney disease, and low back pain
What Wegovy is Wegovy is a GLP-1 receptor agonist produced by Novo Nordisk