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Conversely, inflammatory phyla were notably expanded: Pseudomonadota (Proteobacteria) showed extreme enrichment, suggesting gut inflammation and barrier disruption, while Campylobacterota was significantly increased, consistent with pathobiont overgrowth

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In a human study, Fadini et al

Severe liver or kidney disease impairs glutathione metabolism and clearance

elegans , likely through cell non-autonomous systemic effects