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A short motif in the N-terminal region of -synuclein is critical for both aggregation and function

Using ischemic stroke models in 8-week-old male C57BL/6j mice, induced by transient middle cerebral artery occlusion or bilateral common carotid artery ligation, Exendin-4 (150 g/kg) was administered intravenously

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Apart from the low propensity of the GSAAT(C168S) and GSAAT(C190S) mutants to dimerize, these single substitution mutants not only failed to promote redox-dependent dimerization and oxidation of monomeric GSAAT, but even prevented it

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