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For this, ApoE/ mice were fed a high-fat diet for 4 weeks, after which they were randomly assigned to five groups and treated as follows while continuing on the high-fat diet for an additional month: (I) PBS, (II) Mn/TI@mHSA, (III) P-Mn@mHSA, (IV) P-Mn/TI@mHSA-N, and (V) P-Mn/TI@mHSA

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Tamoxifen (Sigma Aldrich, T5648) was administered by intraperitoneal injection at 160 mg/kg once daily for 5 days