A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin
Chemical Name: 1-(2,6-dichlorobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Molecular Formula: C 18 H 14 N 2 O 2 Molecular Weight: 290.32 g/mol Mechanism of Action: PGC-1/ERR and REV-ERB Pathway Activation PubChem CID: Not yet assigned Mitochondrial & Metabolic Effects Weight Loss & Fat Oxidation 3
As of March 2026, two trials are actively recruiting new participants: the Maintenance trial (NCT06859268, testing dose reduction after initial weight loss) and a new enrollment trial (NCT07232719, 250 participants with obesity or overweight)
At the 12mg dose: 58.6% of participants lost 25% or more of their body weight 39.4% of participants lost 30% or more Those thresholds are typically associated with bariatric surgery
Last reviewed: June 19, 2026 Last updated: June 19, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Focus: Maintenance planning, establishing long-term strategy, evaluating results against goals
