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PMCID: PMC280272

Thyroid C-cell tumours have been observed in rodent studies with GLP-1 receptor agonists, though the relevance to humans remains uncertain

The most common side effects include nausea, upset stomach, constipation, fatigue, and headaches, which typically resolve with time

These receptors control hunger signals and help regulate blood sugar

Changes in hydration Many people on GLP-1 medications also notice: Reduced thirst Feeling full before drinking enough fluids Nausea that discourages drinking Less fluid intake, combined with slower digestion, often results in dehydration of the stool, further worsening constipation