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In support of this idea, ablation of GLP1 receptors in the adult (using AAVCre injected directly into the paraventricular hypothalamic nucleus) resulted in marked obesity whereas constitutive deletion of GLP1 receptors in the paraventricular hypothalamic nucleus (using Sim1Cre) failed to alter energy balance (Table 2) (Burmeister et al., 2017

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In summary, the present findings demonstrated that an elevated plasma L-Cn might precipitate the persistence of HBV infection by exerting an immunosuppressive function, indicating a beneficial effect of low L-Cn level in chronic HBV infection