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The brand states that L-Arginine "increases the production of nitric oxide, promoting the dilation of blood vessels and helping to reduce blood pressure." L-Citrulline, per the brand, "converts to L-Arginine in the body, increasing the production of nitric oxide." L-Arginine Alpha-Ketoglutarate is described by the brand as "a more effective form of L-Arginine that improves circulation." The biological chain the brand is referencing is established in the scientific literature: eNOS in vascular endothelial cells converts L-Arginine into NO and L-Citrulline

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Purity 99% is verified through HPLC analysis and mass spectrometry validation

For crossover trials, the RoB 2.0 tool specific to crossover studies was utilized (Version dated 18 March 2021)

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