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Semaglutide hits one receptor, Tirzepatide hits two, and Retatrutide hits three and in published trials Retatrutide has produced the largest reductions of the group

TRZ was approved in 2022 for the treatment of T2D and obesity, mainly in patients with cardio-metabolic disorders (Boutari et al

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Pregnancy and breastfeeding represent situations where no safety data exists

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Further, male rats had increased mortality, while surviving females displayed a significant decrease in serum IGF-1 and nearly a doubling of infarct volume and sensorimotor deficits (Earnest et al., 2016)