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The LIONESS study, a trial conducted among twenty-two patients with chronic stable angina examined the effects of subcutaneous liraglutide treatment on exercise-induced ischemia ( Conclusion and Future Perspectives Coronary atherosclerosis, vasospasm of epicardial coronary arteries, and structural/functional changes in coronary microcirculation reduce coronary blood flow, which further results in ACS/CCS, vasospastic angina, and MVA, respectively

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New Engl J Med 2003;349:1628-35