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doi: 10.3390/ijms241914857, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 18.Kelley DE, Mandarino LJ

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A plethora of studies have delineated the mechanisms responsible for therapeutic failure in cases of aggressive PC [10, 11]

The preferential fat loss likely results from glucagon receptor activation, which increases resting energy expenditure and promotes fat oxidation as the primary fuel source, sparing protein catabolism for energy needs

Taking the medication earlier in the day might mitigate this

The medication is building up in your system