Annu Rev Biochem (2013) 82:77597
Retatrutide is a new treatment for those who are overweight or living with obesity The medication has not yet received approval or become available It works by targeting three different receptors at the same time Clinical trials to date suggest potential weight loss of up to 24% Side effects seem to be similar to those seen with other GLP-1 medications About Retatrutide Retatrutide is a new treatment for those who are overweight or living with obesity The medication has not yet received approval or become available It works by targeting three different receptors at the same time Clinical trials to date suggest potential weight loss of up to 24% Side effects seem to be similar to those seen with other GLP-1 medications Retatrutide: new weight loss medication in development Retatrutide is a new medication that is currently attracting considerable attention as a potential treatment for overweight and obesity

These cellular transformations contribute significantly to enhanced endurance during exercise, thereby underscoring the critical role that GLP-1 plays in the regulation of mitochondrial function and content in skeletal muscle
2025;39:e153e154
The Results In this study, 3,346 people with obesity, meaning a BMI over 30, but without diabetes started GLP-1 therapy and were compared to 8,343 similar people not using GLP-1 drugs
Personalized treatment is important, as age, sex, and even lifestyle can change how someone reacts to retatrutide