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further investigation is needed.60, 61 Of interest, the time course of HPC activation in mice was closely correlated with temporal changes in serum stem cell factor (SCF) after APAP-induced liver injury, suggesting a potential role of SCF in progenitor cell activation.62, 64 Another study reported increased expression of SCF and its receptor c-kit (progenitor cell marker) in liver after APAP overdose in mice

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doi: 10.4239/wjd.v2.i2.19

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314 Melatonin signaling pathway The mechanisms by which melatonin-related signaling pathways exert their antiaging effects can be summarized as follows (Table 1): (1) Antioxidant function