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doi: 10.1177/1559827609335350 17

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Concurrently, nuclear DNA disintegrates while certain internal structures, including the endoplasmic reticulum, fragment into smaller components

Quite remarkably, in those with low POP levels, the typically robust association between diabetes and obesity was not observed in a nested case-controlled study, suggesting that obesity may exaggerate the metabolic disturbances caused by POPs (perhaps because adipose tissue provides a reservoir for fat-soluble toxins), rather than being directly responsible for the altered metabolism