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A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

GIP receptor activation enhances insulin secretion in response to glucose and appears to reduce food intake through central mechanisms not fully understood

We then performed intraperitoneal glucose tolerance tests (IPGTTs) post-administration of vehicle or 1 nmol/kg exendin-4 to determine the glucose lowering effect of pharmacologically targeting the receptor under these conditions