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Improved tolerability could therefore become an important competitive advantage if these findings translate successfully into clinical studies

Additionally, the activation of TGR5 and FXR (receptors for BAs) inhibits the effector functions of macrophages and promotes their polarization toward the anti-inflammatory M2 phenotype (49)

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Then, increase the dose gradually, taking advantage of the multidose pen-injector when available

That is not a knock on your effort or your goals, it is a statement about what the product can physically do once you understand the absorption problem above