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In women with PCOS women, reduced tissue availability or altered metabolism of inositol and/or inositol-derived mediators contributes to elevated insulin resistance

All these previous meta-analyses were limited by a small number of study participants and only compared the interventions to placebo or metformin, without a comprehensive inclusion of clinical outcomes

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After propensity-score matching, the two cohorts (26,670 in each cohort, mean age 58.0 years, 45.3% women, 14.7% black, 60.3% white, 6.5% Hispanic) were balanced (Supplementary Table 1)