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An increase in CRP values and WBC, neutrophils and monocytes in both high and low-dose subgroups was found, with a concomitant decrease in albumin and lymphocyte levels suggesting an inflammatory reaction

D-Phe7 substitution introduces a D-amino acid configuration at position 7, sterically hindering peptidase access and extending biological activity in preclinical models

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Topical application faces a skin barrier problem

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