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Based on the plethora of symptoms affecting different organs/systems, PASC-affected population could be categorized into four different clusters or sub-phenotypes: Sub-phenotype-1 (33.8%) with cardiac and renal manifestations, Sub-phenotype-2 (32.8%) with respiratory, sleep and anxiety disorders, Sub-phenotype-3 (23.4%) with skeleton-muscular and nervous disorders, and Sub-phenotype-4 (10.1%) with digestive and pulmonary dysfunctions 123,136

Great progress in the past two decades resulted in the identification of the NOX family, consisting of NOX1, NOX2, NOX3, NOX4, NOX5, and dual oxidases DUOX1 and DUOX2 (Yoboue et al

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A doctor may consider prior response, current dose, side effects, blood sugar status, constipation or nausea history, hydration, protein intake, weight-loss plateau patterns, medication access, and long-term goals

The most commonly reported events in active arms were mild and transient: injection site reactions in some subcutaneous subjects, occasional headache, and in some oral dosing arms, minor gastrointestinal tolerance issues

Blood 280a, 1999