semaglutide and surgery Weight loss more effective than obesity drugs: study Semaglutide delivers substantial weight loss

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Saxenda is a very effective treatment option to help people with obesity lose weight

Melina Khan is a trending reporter for the USA TODAY Network - New England, which serves more than a dozen affiliated publications across New England

How to eat if you take a GLP-1 (Ozempic, Wegovy, Mounjaro, Zepbound) How to eat if you take a GLP-1 Medication Understanding Nutrition on GLP-1s Over the past few years, Ive immersed myself in the evolving science and clinical experience surrounding GLP-1 receptor agonists medications you may know as Ozempic, Wegovy, Mounjaro and Zepbound

Phase 2 trial data (published in New England Journal of Medicine, 2023 ): 24.2% average weight loss at 48 weeks with 12 mg dose 22.8% with 8 mg dose Placebo group lost 2.1% Most recent Phase 3 trial data (TRIUMPH-4, December 2025): 28.7% average weight loss at 68 weeks with 12 mg dose 26.4% with 9 mg dose 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% weight loss For context: These are the highest weight loss numbers reported in any clinical trial for a pharmacological obesity treatment

doi: 10.1016/S2468-1253(17)30285-6 176 SeufertJGallwitzB