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18 This reduction of COX-2 leads to decreased levels of inflammation

Taken together, the progressive elucidation and investigation of ALS-related disease-causing genes, the successful construction of disease models through the utilization of technologies such as exon sequencing and gene editing, and the further investigation of the potential molecular regulatory mechanisms between ALS mutant genes and mitochondria will facilitate the opening of a new avenue for the study of targeted therapy for ALS disease

Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N

Ann Surg 261(6):1114-23, 2015

Sperm cryopreservation and DNA methylation: possible implications for ART success and the health of offspring