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Furthermore, NAD+ itself does not easily cross the cell membrane due to its large and charged structure

doi: 10.1016/j.trac.2021.116311 51 AmeroPKhatuaSRodriguez-AguayoCLopez-BeresteinG

They show promising results in animal studies, but human evidence is limited, so we cannot confirm real clinical benefit

Limited human clinical trial data exists

Aronoff, S

News Release February 26, 2024 Latest ConsumerLab Survey Shows Growth in Popularity of Magnesium and Several Smaller Supplements White Plains, New York, February 26, 2024 A recent survey of more than 10,000 people who regularly use dietary supplements shows that supplements that experienced the greatest absolute growth in popularity during 2023 were pregnenolone (+7.5 percentage points), magnesium (+4.8 pts), berberine (+4