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Other investigational compounds like acamprosate, neramexane, and AM-101 have also shown promise in clinical trials, though none are yet approved, highlighting the ongoing research need (Che et al., 2025)

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Abstract Neurodegenerative diseases represent an expanding global health challenge, with rapidly increasing prevalence and substantial economic impact

Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL

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This includes affecting metalloproteinases (MMPs) and their inhibitors