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Emerg Med Int

In experimental and clinical research, berberine has been shown to influence cellular energy metabolism, including activation of AMP-activated protein kinase (AMPK), a key regulator of glucose and fat metabolism

Results We demonstrated that this peptide-liposome-small molecule machinery targets AML and consequently induces cell apoptosis both in vitro and in vivo through three disparate mechanisms: (I) Oridonin, as a Michael acceptor molecule, inhibits GSH function through covalent bonding, triggering an initial imbalance of oxidative stress

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What surprises them is that a scar they have had for three years starts fading, or a patch of pigmentation that has not moved in two years begins to clear

Phornphutkul C, Wu KY, Gruppuso PA