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2023 NEJM Phase 2 obesity trial used a starting dose of 2 mg once weekly with dose escalation every 4 weeks, reaching a maximum tested maintenance dose of 12 mg/week [1][2]

2024 Biomolecules review, suggests that GLP-1 agonists do not have a direct toxic effect on thyroid cells

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Go urgently for severe abdominal pain, trouble breathing, facial swelling, persistent vomiting, or signs of dehydration

As your body adjusts and these effects fade, caloric consumption can creep upward without conscious awareness

LDL cholesterol (often called 'bad cholesterol') and total cholesterol also tend to decrease in semaglutide users, though the magnitude varies