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One caveat: a 2025 joint advisory from four major medical societies recommends temporarily limiting high-fiber foods during the first few days of starting or increasing your dose, when nausea is most likely
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Moreover, patients losing 20-30% of their body weight also contributes to blood pressure lowering effects as well and going back to the earlier graph with 2 out of 3 patients not even being in the obese BMI category, suggests a large number of patients were probably able to reduce dose or stop their blood pressure medicine entirely but since they only had the data for a couple weeks we have to wait for confirmation on that
Hence, our data also support a previously unrecognized function of GSH in the protection against FA toxicity, and an evolutionary conserved mechanism that maintains GSH:GSSG balance by salvaging reduced GSH from FA-GSH products
rather, maintaining steady weekly dosing produced the most reliable appetite suppression and metabolic improvements