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Phentermine's catecholaminergic effects increase energy expenditure, whereas GLP-1 agents primarily suppress appetite through gut-brain signaling

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d-e , HCC-1806 cells were transduced with CRISPR-Cas9 lentiviral vector containing sgRNA guides targeting GGT1 and maintained as a polyclonal population

Mounjaro Mounjaro (tirzepatide) represents the newest alternative, working on both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors