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doi: 10.1089/jmf.2013.2849, 36

Sugars have been associated with various signalling pathways, which initiate depolarisation of the L-cell membrane causing an elevated concentration of cytosolic Ca 2+ , which in turn induces GLP-1 secretion

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Management of ARIA may include discontinuation of the medication either temporarily or indefinitely To ensure that ARIA is identified should it occur, the appropriate use recommendations (AUR, i.e., guidelines for clinicians to administer new therapies safely and effectively) for lecanemab suggest health care professionals obtain MRI scans of the brain before the 5th, 7th, 14th and 26th infusions, in addition to a baseline scan before starting treatment