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Both MOTS-c and metformin activate AMPK, improve insulin sensitivity, and lower blood glucose

Exp Neurol 231:171180 Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z et al (2010) Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle

[DOI] [PubMed] [Google Scholar] 85.Giugliano D., Scappaticcio L., Longo M., Caruso P., Maiorino M.I., Bellastella G., Ceriello A., Chiodini P., Esposito K

Aim for at least 1 gram of protein per pound of ideal body weight daily

It should support a lifestyle plan, not replace one

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