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Patients maintaining semaglutide treatment long-term show sustained liver fat reductions, suggesting that continued GLP-1 receptor activation prevents hepatic fat reaccumulation

Clinical trials show that those taking the drug lost up to 15.3kg (2 stone and 6lbs), on average, over the space of 15 months, compared to just 2.6kg (6lbs) in the placebo group

The heterodimerization of PPARs with retinoid X receptors is essential for enterocyte differentiation, significantly influencing villus development and the repair of crypt integrity following injury

Because they do not compete for the same 'machinery' in the body, they do not interfere with each other's effectiveness or safety