Given the short half-life of endogenous GLP-1, local vagal signaling likely mediates the effect of intestinal GLP-1 release on food intake as well 123
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Over 48 weeks, it drove up to 24% weight loss and major glycemic gains, beating both semaglutide and tirzepatide
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Future research may pay more attention to other activities like -arrestin recruitment or ligand-receptor affinity