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While higher doses of retatrutide are linked to more weight loss, dosing is titrated up over time, just like with other injectables

Three strength combinations are available: 2 mg semaglutide / 0.1 mg methylcobalamin (starting dose) 5 mg semaglutide / 0.1 mg methylcobalamin (intermediate dose) 12 mg semaglutide / 0.1 mg methylcobalamin (higher dose) The methylcobalamin dose remains constant at 0.1 mg (100 mcg) across all three strengths

This leads to an increase in the expression of caspase 3 , ICAM, TNF- , or IL-6 genes