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15 week old ZDF rats displayed hyperglycemia, MNCV and SNCV deficits, thermal and mechanical hypoalgesia, tactile allodynia, and 26% loss of intraepidermal nerve fibers

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45 Because this study had no control group it is impossible to establish whether the observed benefits were due to a placebo effect

Statements Author contributions AC, LM, and PS conceptualized the topic and structure of the review