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DNA damage promotes mutations of suppressor in tumor such as calcium/calmodulin dependent serine protein kinase (CASK), p53, as well as stimulation of the epidermal growth factor receptor (EFGR) signaling pathway, which are important early events in gastric carcinogenesis (86, 87)
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Stud Nat Prod Chem 33:785812 Linnaeus C (1753) Species Plantarum
Aurein 1.2 is an attractive ACP, an AMP derived from the frog Litoria aurea , that has shown strong anti-tumor capabilities in vitro and has been found to fight against 55 distinct types of tumor cell lines while showing tiny cytotoxicity (115)